Drd1^tm2.2Stl
Targeted Allele Detail

Summary

• Symbol: Drd1^tm2.2Stl
• Name: dopamine receptor D1; targeted mutation 2.2, Susumu Tonegawa
• MGI ID: MGI:5603922
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^tm2.2Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211355
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced 5' of the targeted gene's single exon and an FRT-loxP-(neo-tk)-FRT-loxP (LFNT) cassette was introduced 3'. The floxed exon was deleted by transient transfection of a Cre recombinase expression vector in the ES cells (J:211355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 70 strains or lines available

References

• Original: J:211355 Sarinana J, et al., Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8245-50
• All: 1 reference(s)