Tg(ICAM1)4Grom
Transgene Detail

Summary

• Symbol: Tg(ICAM1)4Grom
• Name: transgene insertion 4, Matthias Gromeier
• MGI ID: MGI:5604232
• Synonyms: HsICAM-1 tg
• Transgene: Tg(ICAM1)4Grom Location: unknown
• Alliance: Tg(ICAM1)4Grom page

Transgene origin

• Strain of Origin: FVB/NHsd

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ICAM1)4Grom expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ICAM1 (3383)

  Icam1

  (MGI:96392)

• Mutation details: A ~39 kbp segment was isolated from BAC CTD-2369P2 containing the entire human intercellular adhesion molecule 1 gene (ICAM1), including ~18.9 kbp upstream and ~4.6 kbp downstream. Five founder lines were generated and founder line 4 was determined to have hICAM-1 expression intensity and tissue distribution similar to human. (J:92607)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92607 Dufresne AT, et al., A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13636-41
• All: 2 reference(s)