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Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Transgene Detail
Summary
Symbol: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Name: transgene insertion, David M Ornitz
MGI ID: MGI:5604241
Synonyms: TRE-caFgfr1, TRE-caFgfr1-myc, TRE-Fgfr31c(R248C)-c-myc
Transgene: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor  Location: unknown  
Alliance: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified. (J:211151)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:211151 Cilvik SN, et al., Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS One. 2013;8(12):e82979
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory