Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Transgene Detail
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Symbol: |
Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor |
Name: |
transgene insertion, David M Ornitz |
MGI ID: |
MGI:5604241 |
Synonyms: |
TRE-caFgfr1, TRE-caFgfr1-myc, TRE-Fgfr31c(R248C)-c-myc |
Transgene: |
Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor Location: unknown
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Alliance: |
Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor page
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Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: This transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified.
(J:211151)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:211151 Cilvik SN, et al., Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS One. 2013;8(12):e82979 |
All: |
4 reference(s) |
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