About   Help   FAQ
Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Transgene Detail
Summary
Symbol: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Name: transgene insertion, David M Ornitz
MGI ID: MGI:5604241
Synonyms: TRE-caFgfr1, TRE-caFgfr1-myc, TRE-Fgfr31c(R248C)-c-myc
Transgene: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor  Location: unknown  
Alliance: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified. (J:211151)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:211151 Cilvik SN, et al., Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS One. 2013;8(12):e82979
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory