Fn1^tm1.1Sakai
Targeted Allele Detail

Summary

• Symbol: Fn1^tm1.1Sakai
• Name: fibronectin 1; targeted mutation 1.1, Takao Sakai
• MGI ID: MGI:5604386
• Synonyms: Fn(fl)
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm1.1Sakai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and a neo-tk cassette flanked by loxP sites were inserted into the MscI site of the 5' untranslated region and NheI site within the first intron, respectively. The loxP flanked neo-tk cassette was removed via Cre-mediated recombination, leaving the first coding exon flanked by loxP sites. (J:214945)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:214945 Moriya K, et al., A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology. 2011 May;140(5):1653-63
• All: 4 reference(s)