Bhlha9^tm1Nba
Targeted Allele Detail

Summary

• Symbol: Bhlha9^tm1Nba
• Name: basic helix-loop-helix family, member a9; targeted mutation 1, Nissim Ben-Arie
• MGI ID: MGI:5604430
• Synonyms: Fingerin null
• Gene: Bhlha9 Location: Chr11:76563296-76564502 bp, + strand Genetic Position: Chr11, 45.97 cM
• Alliance: Bhlha9^tm1Nba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214852
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector eliminates the coding sequence and replaces it by a promoterless nuclear lacZ reporter gene and a Neomycin resistance gene. X-gal staining is seen in the limb bud as early as E9.5. (J:214852)

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bhlha9 Mutation: 10 strains or lines available

References

• Original: J:214852 Schatz O, et al., Gene dosage of the transcription factor Fingerin (bHLHA9) affects digit development and links syndactyly to ectrodactyly. Hum Mol Genet. 2014 Oct 15;23(20):5394-401
• All: 2 reference(s)