Brinp1^tm1.1Pib
Targeted Allele Detail

Summary

• Symbol: Brinp1^tm1.1Pib
• Name: bone morphogenic protein/retinoic acid inducible neural specific 1; targeted mutation 1.1, Phillip I Bird
• MGI ID: MGI:5604542
• Gene: Brinp1 Location: Chr4:68679751-68872634 bp, - strand Genetic Position: Chr4, 35.03 cM, cytoband C2
• Alliance: Brinp1^tm1.1Pib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231288
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This mutation was generated from the conditional allele by cre recombinase excision of exon 3 and a frt sequence-flanked neomycin resistance cassette in intron 3, leaving a single loxP site. (J:231288)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brinp1 Mutation: 30 strains or lines available

References

• Original: J:231288 Berkowicz SR, et al., Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. Mol Autism. 2016;7:22
• All: 1 reference(s)