Esr2^tm1.1Ksk
Targeted Allele Detail

Summary

• Symbol: Esr2^tm1.1Ksk
• Name: estrogen receptor 2 (beta); targeted mutation 1.1, Kenneth S Korach
• MGI ID: MGI:5604770
• Synonyms: Ex3BERKO, Ex3betaERKO
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^tm1.1Ksk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette and exon 3 were subsequently removed from properly targeted mice by cre excision. (J:198474)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 36 strains or lines available

References

• Original: J:198474 Binder AK, et al., The absence of ER-beta results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles. Endocrinology. 2013 Jun;154(6):2174-87
• All: 5 reference(s)