Cyp26b1^tm1Dcp
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm1Dcp
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, David C Page
• MGI ID: MGI:5604888
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm1Dcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215225
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 and the coding region of exon 7 were replaced by a loxP-flanked PGK-neomycin cassette via homologous recombination. (J:215225)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:215225 Koubova J, et al., Retinoic acid activates two pathways required for meiosis in mice. PLoS Genet. 2014 Aug;10(8):e1004541
• All: 1 reference(s)