Jagn1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Jagn1^{tm1c(EUCOMM)Hmgu}
• Name: jagunal homolog 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5604904
• Synonyms: Jagn1^fl
• Gene: Jagn1 Location: Chr6:113419530-113425190 bp, + strand Genetic Position: Chr6, 52.76 cM
• Alliance: Jagn1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Jagn1 gene page

Mutation origin

• Mutant Cell Line: HEPD0614_4_D07
• Germline Transmission: Earliest citation of germline transmission: J:214828
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 113423780 of Chromosome 6 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. The critical exon 2 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neo cassette and left exon 2 floxed. (J:214828)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jagn1 Mutation: 8 strains or lines available

References

• Original: J:214828 Wirnsberger G, et al., Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 2014 Sep;46(9):1028-33
• All: 2 reference(s)