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Esr1tm2.1(cre)And
Targeted Allele Detail
Summary
Symbol: Esr1tm2.1(cre)And
Name: estrogen receptor 1 (alpha); targeted mutation 2.1, David J Anderson
MGI ID: MGI:5605085
Gene: Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance: Esr1tm2.1(cre)And page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207677
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (RMCE-ready, Recombinase)
Mutation:    Insertion
 
Esr1tm2.1(cre)And expression driven by 1 gene
 
Mutation detailsThe targeting vector was designed to insert an attP site, a 2A oligopeptide (mediates ribosomal skipping), the Cre recombinase gene, a FRT-flanked PGKneo-polyA cassette, and an attP site within the 3' UTR of the gene. Flpe-mediated recombination removed the neo cassette. (J:207677)
Recombinase
activity
Activity:
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Driver: Esr1 (mouse)
Summary of all recombinase alleles driven by Esr1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  68 strains or lines available
References
Original:  J:207677 Lee H, et al., Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus. Nature. 2014 May 29;509(7502):627-32
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory