Abcg8^tm1.1Hobb
Targeted Allele Detail

Summary

• Symbol: Abcg8^tm1.1Hobb
• Name: ATP binding cassette subfamily G member 8; targeted mutation 1.1, Helen H Hobbs
• MGI ID: MGI:5605297
• Gene: Abcg8 Location: Chr17:84983730-85007761 bp, + strand Genetic Position: Chr17, 55.02 cM
• Alliance: Abcg8^tm1.1Hobb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215443
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The Abcg5 and Abcg8 genes are in a head to head orientation. A loxP site and FRT-flanked neomycin cassette were introduced into intron 2 of the Abcg5 gene, and a loxP site was placed in intron 1 of the Abcg8 gene, generating a second allele, Abcg5^tm1.1Hobb. Flpe-mediated recombination removed the FRT-flanked neomycin cassette. (J:215443)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcg8 Mutation: 30 strains or lines available

References

• Original: J:215443 Wang J, et al., Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 2015 Feb;56(2):319-30
• All: 1 reference(s)