Opa1^tm1Lsc
Targeted Allele Detail

Summary

• Symbol: Opa1^tm1Lsc
• Name: OPA1, mitochondrial dynamin like GTPase; targeted mutation 1, Luca Scorrano
• MGI ID: MGI:5605402
• Synonyms: Opa1^flx
• Gene: Opa1 Location: Chr16:29398152-29473702 bp, + strand Genetic Position: Chr16, 20.65 cM, cytoband B2
• Alliance: Opa1^tm1Lsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214492
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced between intron 1 and exon 2 and a phosphoglycerate kinase (PGK) promoter-driven neomycin resistance gene, flanked by two FRT sequences and with one loxP sequence downstream, was inserted in intron 3. (J:214492)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opa1 Mutation: 56 strains or lines available

References

• Original: J:214492 Cogliati S, et al., Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013 Sep 26;155(1):160-71
• All: 8 reference(s)