Stx1b^tm1Tmis
Targeted Allele Detail

Summary

• Symbol: Stx1b^tm1Tmis
• Name: syntaxin 1B; targeted mutation 1, Tatsuya Mishima
• MGI ID: MGI:5605503
• Gene: Stx1b Location: Chr7:127403072-127423703 bp, - strand Genetic Position: Chr7, 69.75 cM
• Alliance: Stx1b^tm1Tmis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the region from exon 9 to exon 10 that encodes the H3 and transmembrane domains with a neomycin-resistant gene and attached the diphtheria toxin gene to the 3' end of the construct. Western blot analysis confirmed absence of protein in homozygotes. (J:214474)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx1b Mutation: 21 strains or lines available

References

• Original: J:214474 Mishima T, et al., Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses. PLoS One. 2014;9(2):e90004
• All: 1 reference(s)