Txlng^tm1.2Star
Targeted Allele Detail

Summary

• Symbol: Txlng^tm1.2Star
• Name: taxilin gamma; targeted mutation 1.2, Rene St-Arnaud
• MGI ID: MGI:5605561
• Synonyms: Fiat^-
• Gene: Txlng Location: ChrX:161561915-161612450 bp, - strand Genetic Position: ChrX, 74.99 cM
• Alliance: Txlng^tm1.2Star page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208796
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 34 bp loxP sequence was inserted upstream from exon 1 and a 6.4 kb PGK-neo-HsvTK cassette flanked by two loxP sites was introduced within intron 1. The loxP-flanked selection cassette and exon 1 were removed via cre-mediated recombination. RT-qPCR confirmed reduced mRNA expression in heterozygous females. (J:208796)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txlng Mutation: 45 strains or lines available

References

• Original: J:208796 Hekmatnejad B, et al., Altered gene dosage confirms the genetic interaction between FIAT and alphaNAC. Gene. 2014 Apr 1;538(2):328-33
• All: 2 reference(s)