Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Zhengui Xia
• MGI ID: MGI:5605718
• Synonyms: caMEK5-eGFP, ROSA caMEK5-eGFP^loxP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206948
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct consisting of a chicken beta-actin promoter, a floxed pgk-neo stop cassette, and a cDNA encoding a constitutive active Map2k5 fused in frame at the 3' end of an EGFP cDNA was inserted via homologous recombination. (J:206948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:206948 Wang W, et al., Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci. 2014 Feb 5;34(6):2130-47
• All: 2 reference(s)