Atp2b1^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Atp2b1^{tm1b(KOMP)Wtsi}
• Name: ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5605735
• Synonyms: Atp2b1^-
• Gene: Atp2b1 Location: Chr10:98750268-98862005 bp, + strand Genetic Position: Chr10, 50.97 cM, cytoband C3
• Alliance: Atp2b1^{tm1b(KOMP)Wtsi} page
• IMPC: Atp2b1 gene page

Atp2b1^{tm1b(KOMP)Wtsi}/Atp2b1^{tm1b(KOMP)Wtsi} mice exhibit embryonic lethality, with embryos seen at E3.5 as early blalstocysts but no embryos at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form outgrowths with an inner cell mass but limited/no trophectoderm or primitive cells.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: EPD0797_1_C06
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Atp2b1^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:	54 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp2b1 Mutation: 66 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)