Atg16l1^tm2.1Mvlc
Targeted Allele Detail

Summary

• Symbol: Atg16l1^tm2.1Mvlc
• Name: autophagy related 16 like 1; targeted mutation 2.1, Menno van Lookeren Campagne
• MGI ID: MGI:5605965
• Synonyms: Atg16l1^loxp
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^tm2.1Mvlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:206931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 44 strains or lines available

References

• Original: J:206931 Murthy A, et al., A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature. 2014 Feb 27;506(7489):456-62
• All: 5 reference(s)