mt-Tk^m1
Spontaneous Allele Detail

Summary

• Symbol: mt-Tk^m1
• Name: mitochondrially encoded tRNA lysine; mutation 1
• MGI ID: MGI:5606283
• Synonyms: tRNA^Lys7731
• Gene: mt-Tk Location: ChrMT:7700-7764 bp, + strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Tk^m1 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Mitochondria with a ChrM:7731G>A mutation in the mitochondrially encoded lysine tRNA were identified in P29 cells. Cybrids created in B82 cells lacking mitochondrial DNA and then transferred to TT2-F ES cells were introduced into 8-cell stage embryos of ICR mice. Cybrids were estimated to have 70% mutant DNA. (J:206827)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Tk Mutation: 0 strains or lines available

References

• Original: J:206827 Shimizu A, et al., Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9
• All: 3 reference(s)