Cd22^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cd22^m2Btlr
• Name: CD22 antigen; mutation 2, Bruce Beutler
• MGI ID: MGI:5607164
• Synonyms: crullers
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The crullers mutation is in Cd22: a T to C transition at base pair 30,869,883 (v38) on chromosome 7, or base pair 10,460 in the GenBank genomic region NC_000073. This corresponds to nucleotide 2,045 in the mRNA sequence NM_009845 within exon 8 of 14 total exons or nucleotide 2,170 in the mRNA sequence NM_001043317 in exon 10 of 16 total exons. The mutation results in a serine (S) to proline (P) substitution at position 603 (S603P) in both CD22 isoforms. (J:215821)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 64 strains or lines available

References

• Original: J:215821 Zeng M, et al., Mutagenetix entry for crullers. MGI Direct Data Submission. 2014
• All: 1 reference(s)