Tg(Arc-cre/ERT2)MRhn
Transgene Detail

Summary

• Symbol: Tg(Arc-cre/ERT2)MRhn
• Name: transgene insertion M, Rene Hen
• MGI ID: MGI:5607252
• Synonyms: ArcCreER^T2
• Transgene: Tg(Arc-cre/ERT2)MRhn Location: unknown
• Alliance: Tg(Arc-cre/ERT2)MRhn page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Arc-cre/ERT2)MRhn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Arc (MGI:88067)

• Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP23-429N15) containing the entire mouse activity regulated cytoskeletal-associated protein (Arc) gene. A CreERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand-binding domain), followed by an SV40 polyadenylation sequence, was inserted into the translation initiation site of the gene. Founder lines M and F were established and maintained. (J:215456)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Arc (mouse) Summary of all recombinase alleles driven by Arc. Comparative matrix view of recombinase activities Alliance mouse Arc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:215456 Denny CA, et al., Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 2014 Jul 2;83(1):189-201
• All: 13 reference(s)