Cavin4^tm1.2Tue
Targeted Allele Detail

Summary

• Symbol: Cavin4^tm1.2Tue
• Name: caveolae associated 4; targeted mutation 1.2, Tomomi Ueyama
• MGI ID: MGI:5607305
• Synonyms: MURC^-
• Gene: Cavin4 Location: Chr4:48663514-48673492 bp, + strand Genetic Position: Chr4, 26.23 cM, cytoband B2
• Alliance: Cavin4^tm1.2Tue page

Attenuation of phenylephrine-induced cardiac hypertrophy in Cavin4^tm1.2Tue/Cavin4^tm1.2Tue mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207401
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted in the 5' untranslated region and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1. (J:207401)

Generation of the Cavin4^tm1.1Tue and Cavin4^tm1.2Tue alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cavin4 Mutation: 15 strains or lines available

References

• Original: J:207401 Ogata T, et al., MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3811-6
• All: 4 reference(s)