Hprt1^{tm5(Camk2a-BACE1)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm5(Camk2a-BACE1)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, Genoway
• MGI ID: MGI:5607312
• Synonyms: PLB4
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm5(Camk2a-BACE1)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215577
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm5(Camk2a-BACE1)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BACE1 (23621)

  Bace1

  (MGI:1346542)

• Mutation details: The construct targeted to the locus the human BACE1 gene under the control of Camk2a promoter. Western blot analysis of brain lysates indicates that BACE1 expression levels are about 1.8-fold and 2.2-fold higher at 6 and 12 months of age, respectively. (J:215577)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:215577 Plucinska K, et al., Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes. J Neurosci. 2014 Aug 6;34(32):10710-28
• All: 4 reference(s)