Mst1r^{tm2(Mst1r*)Sew}
Targeted Allele Detail

Summary

• Symbol: Mst1r^{tm2(Mst1r*)Sew}
• Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); targeted mutation 2, Susan E Waltz
• MGI ID: MGI:5607440
• Synonyms: FL-Ron
• Gene: Mst1r Location: Chr9:107784072-107797582 bp, + strand Genetic Position: Chr9, 59.07 cM, cytoband F1
• Alliance: Mst1r^{tm2(Mst1r*)Sew} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215969
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a 2.0-kb cDNA fragment encoding exons 9 through 19 and a neo cassette was used to disrupt exons 8 through 12. Elimination of the alternative transcription start site in intron 10 results in expression of the full length (FL) mRNA transcript, but not the short-form (SF) transcript. RT-PCR analysis on spleen, bone marrow, and testis detected only long form transcript. (J:215969)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mst1r Mutation: 61 strains or lines available

References

• Original: J:215969 Wetzel CC, et al., Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G253-61
• All: 1 reference(s)