Cnot3^tm1.1Tya
Targeted Allele Detail

Summary

• Symbol: Cnot3^tm1.1Tya
• Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1.1, Tadashi Yamamoto
• MGI ID: MGI:5607530
• Synonyms: Cnot3^-
• Gene: Cnot3 Location: Chr7:3648267-3664108 bp, + strand Genetic Position: Chr7, 2.1 cM
• Alliance: Cnot3^tm1.1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180033
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette flanked by two loxP sites was inserted in the intron preceding exon 2 and another loxP site was inserted following exon 9. Both the PGK-neo cassette and exons 2-9 were removed via cre-mediated recombination. (J:180033)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot3 Mutation: 35 strains or lines available

References

• Original: J:180033 Morita M, et al., Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J. 2011 Nov 16;30(22):4678-91
• All: 3 reference(s)