Chrne^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Chrne^m1Btlr
• Name: cholinergic receptor, nicotinic, epsilon polypeptide; mutation 1, Bruce Beutler
• MGI ID: MGI:5607645
• Synonyms: pip-squeak
• Gene: Chrne Location: Chr11:70505709-70510042 bp, - strand Genetic Position: Chr11, 43.14 cM
• Alliance: Chrne^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is an A to T transversion at base pair 70,615,130 (v38) on chromosome 11, or base pair 4,501 in the GenBank genomic region NC_000077. The mutation is located within intron 11, two nucleotides from the next, and final, exon (exon 12). It is not yet known how the pip-squeak mutation affects splicing of the gene. The locations of putative cryptic acceptor sites within exon 12 are unknown. (J:216046)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrne Mutation: 22 strains or lines available

References

• Original: J:216046 Sorelle J, et al., Mutagenetix entry for pip-squeak. Updated on December 8, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)