Nlrp3^M6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^M6Btlr
• Name: NLR family, pyrin domain containing 3; mutation 6, Bruce Beutler
• MGI ID: MGI:5607728
• Synonyms: Nlrp3^D946G, Park3
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^M6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is an A to G transition at base pair 59,565,850 (v38) on chromosome 11, or base pair 24,282 in the GenBank genomic region NC_000077. This corresponds to nucleotide 3,063 in the mRNA sequence NM_145827, within exon 4 of 10 total exons. The mutation results in an aspartic acid (D) to glycine (G) substitution at position 946 (D946G) in the NLRP3 protein, and is strongly predicted by Polyphen-2 to be benign (score = 0.017). (J:216047)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 64 strains or lines available

References

• Original: J:216047 Shi H, et al., Mutagenetix entry for Park3. Updated on December 2, 2014. MGI Direct Data Submission. 2014
• All: 2 reference(s)