Nlrp3^M7Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^M7Btlr
• Name: NLR family, pyrin domain containing 3; mutation 7, Bruce Beutler
• MGI ID: MGI:5607730
• Synonyms: Park4
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^M7Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is an A to G transition at base pair 59,549,531 (v38) on chromosome 11, or base pair 7,963 in the GenBank genomic region NC_000077. This corresponds to residue 2,159 in the mRNA sequence NM_145827, within exon 4 of 10 total exons. The mutation results in a methionine (M) to valine (V) substitution at position 645 (M645V) in the protein. (J:216048)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 64 strains or lines available

References

• Original: J:216048 Shi H, et al., Mutagenetix entry for Park4. Updated on December 2, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)