Kcnq3^tm1.1Avtz
Targeted Allele Detail

Summary

• Symbol: Kcnq3^tm1.1Avtz
• Name: potassium voltage-gated channel, subfamily Q, member 3; targeted mutation 1.1, Anastasios V Tzingounis
• MGI ID: MGI:5607736
• Synonyms: Kcnq3^fl
• Gene: Kcnq3 Location: Chr15:65858236-66158491 bp, - strand Genetic Position: Chr15, 29.16 cM
• Alliance: Kcnq3^tm1.1Avtz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6J x 129/Sv)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2-4 were floxed and an FRT flanked neomycin cassette was inserted via homologous recombination. Flp mediated recombination removed the neomycin cassette. (J:208109)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnq3 Mutation: 48 strains or lines available

References

• Original: J:208109 Soh H, et al., Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability. J Neurosci. 2014 Apr 9;34(15):5311-21
• All: 2 reference(s)