Fas^{tm1.1(ALPP)Chnd}
Targeted Allele Detail

Summary

• Symbol: Fas^{tm1.1(ALPP)Chnd}
• Name: Fas cell surface death receptor; targeted mutation 1.1, Christopher Henderson
• MGI ID: MGI:5607749
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^{tm1.1(ALPP)Chnd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Using a BAC-based targeting approach, a loxP-splice acceptor (SA) site was introduced to intron 1 of the Fas gene and an FRT-PGK-Neo-FRT-loxP-SA-human placental alkaline phosphatase (PLAP)-pA was placed in intron 9. Flp-mediated recombination removed the neomycin cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

Notes

ES cell line = CSL2J2

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)