Fas^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Fas^m1Btlr
• Name: Fas cell surface death receptor; mutation 1, Bruce Beutler
• MGI ID: MGI:5607750
• Synonyms: cherry
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a T to C transition at base pair 34,327,140 (v38) on chromosome 19 or base pair 36,482 in the GenBank genomic region NC_000085 encoding Fas. The mutation site corresponds to nucleotide 856 in the mRNA sequence NM_007987, within exon 9 of 9 total exons. Transcript variant 2 (NM_001146708) is not affected by the cherry mutation. The mutation results in a valine (V) to alanine (A) substitution at amino acid position 267 (V267A) in the Fas protein. (J:216052)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

References

• Original: J:216052 Zeng M, et al., Mutagenetix entry for cherry. Updated September 21, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)