Semg1^tm1Kemi
Targeted Allele Detail

Summary

• Symbol: Semg1^tm1Kemi
• Name: semenogelin 1; targeted mutation 1, Kenji Miyado
• MGI ID: MGI:5607932
• Gene: Semg1 Location: Chr2:164077849-164080261 bp, - strand Genetic Position: Chr2, 84.82 cM
• Alliance: Semg1^tm1Kemi page

Seminal vesicle appearance and absence of copulatory plugs in Semg1^tm1Kemi/Semg1^tm1Kemi and Semg1^tm2Kemi/Semg1^tm2Kemi mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207389
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced all 3 exons via homologous recombination. Absence of protein expression was confirmed by SDS/PAGE analysis using total proteins from seminal vesicles. (J:207389)

Generation of the Semg1^tm1Kemi allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Semg1 Mutation: 30 strains or lines available

Notes

In J:207389 the alleles Svs2^tm1Kemi and Svs2^tm2Kemi were reported to give the same results and data were pooled for both alleles.

References

• Original: J:207389 Kawano N, et al., Seminal vesicle protein SVS2 is required for sperm survival in the uterus. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4145-50
• All: 3 reference(s)