Otx2^tm10Sia
Targeted Allele Detail

Summary

• Symbol: Otx2^tm10Sia
• Name: orthodenticle homeobox 2; targeted mutation 10, Shinichi Aizawa
• MGI ID: MGI:5608496
• Synonyms: Otx2^{deltaAN1deltaAN2}
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm10Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207608
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.5 kb fragment containing both anterior neuroectoderm enhancers 1 and 2 was replaced with a floxed pgk-neo cassette via homologous recombination. (J:207608)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:207608 Kurokawa D, et al., Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers. Dev Biol. 2014 Mar 15;387(2):203-13
• All: 1 reference(s)