Scn11a^tm1Gsk
Targeted Allele Detail

Summary

• Symbol: Scn11a^tm1Gsk
• Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, GlaxoSmithKline
• MGI ID: MGI:5608917
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^tm1Gsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216497
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES/lacZpA cassette followed by a floxed neo cassette was inserted into the end of exon 5 resulting in the deletion of exons 6 and 7. (J:216497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 88 strains or lines available

References

• Original: J:216497 Maingret F, et al., Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism. J Gen Physiol. 2008 Mar;131(3):211-25
• All: 5 reference(s)