Cldn4^tm1.1Jhou
Targeted Allele Detail

Summary

• Symbol: Cldn4^tm1.1Jhou
• Name: claudin 4; targeted mutation 1.1, Jianghui Hou
• MGI ID: MGI:5609165
• Synonyms: claudin-4^flox
• Gene: Cldn4 Location: Chr5:134973977-134975788 bp, - strand Genetic Position: Chr5, 74.9 cM
• Alliance: Cldn4^tm1.1Jhou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216399
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The frt-flanked PGK-neo cassette was removed via Flp-mediated recombination leaving exon 1 flanked by loxP sites. (J:216399)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn4 Mutation: 10 strains or lines available

References

• Original: J:216399 Gong Y, et al., The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3766-74
• All: 1 reference(s)