Rspo3^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Rspo3^tm1.1Arte
• Name: R-spondin 3; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5609537
• Gene: Rspo3 Location: Chr10:29329102-29411863 bp, - strand Genetic Position: Chr10, 16.64 cM, cytoband A4
• Alliance: Rspo3^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. RT-PCR confirmed the absence of transcript expression. (J:215739)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rspo3 Mutation: 13 strains or lines available

References

• Original: J:215739 Kazanskaya O, et al., The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64
• All: 4 reference(s)