Summary |
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Variant origin |
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Variant description |
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Notes |
Trait Annotation
Mapping and Phenotype information for this QTL, its variants and associated markersJ:170533The mice used in this study were from the F16 generation of the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).The authors indicated 70 trait-specific QTL mapping to 64 locations,and of these 70 a total of 17 are significant at the genome-wide level. Fifty three are significant at the chromosome level. The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).The authors mentioned that phenotypic variation in response to glucose stress was indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution pergram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance. Phenotypes were as follows:AUC_10wks indicates under the curve at 10 weeksAUC_20wks indicates area under the curve at 20 weeksbGLC_10wks indicates basal glucose level at 10 weeksbGLC_20wks indicates basal glucose level at 20 weeks,GLC indicates serum glucose level at necropsyINS indicates serum insulin level at necropsyChr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime6 Ddiab17 Ddiab6a AUC_20wks 3.24 48.94 48.02 51.576 Ddiab18 Ddiab6b bGLC_20wks 2.86 78 77.21 79.746 *Ddiab19 Ddiab6c AUC_20wks 7.32 88.54 84.28 91.816 *Ddiab20 Ddiab6d INS 8.85 107.02 100.75 115.436 Ddiab20 Ddiab6d nGLC 3.19 107.02 6 Ddiab20 Ddiab6d AUC_20wks 3.43 107.21 Table 1 notes the presence of glucose and/or insulin affecting genes within the mapped QTL interval as marker |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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