Summary |
|
||||||||||
Variant origin |
|
||||||||||
Variant description |
|
||||||||||
Notes |
Trait Annotation
Mapping and Phenotype information for this QTL, its variants and associated markersJ:170533The mice used in this study were from the F16 generation of the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).The authors indicated 70 trait-specific QTL mapping to 64 locations,and of these 70 a total of 17 are significant at the genome-widelevel. Fifty three are significant at the chromosome level. The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).The authors mentioned that phenotypic variation in response to glucose stress was indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance. Phenotypes were as follows:AUC_10wks indicates under the curve at 10 weeksAUC_20wks indicates area under the curve at 20 weeksbGLC_10wks indicates basal glucose level at 10 weeksbGLC_20wks indicates basal glucoselevel at 20weeks,GLC indicates serum glucose level at necropsyINS indicates serum insulin level at necropsyChr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime2 *Ddiab4 Ddiab2a AUC_10wks 4.06 59.26 58.53 61.582 *Ddiab5 Ddiab2b INS 4.1369.2 67.96 70.352 Ddiab6 Ddiab2c GLC 3.3 73.81 71.73 76.292 Ddiab7 Ddiab2d GLC 3.38 99.06 93.29 99.822 Ddiab8 Ddiab2e INS 3.6 103.71 102.74 106.632 *Ddiab9 Ddiab2f AUC_20wks 4.18 145.71 145.01 147.25Table1notes the presence of glucose and/or insulin affecting genes within the mapped QTL interval as marker G6pc2 (glucose-6-phosphatase, catalytic 2), for QTL Ddiab5; and markers Insm1 and Nkx2-2 within the interval of Ddiab9. |
||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|