Ddiab4^SM/J
QTL Variant Detail

Summary

• QTL variant: Ddiab4^SM/J
• Name: diet based diabetes 4; SM/J
• MGI ID: MGI:5609697
• QTL: Ddiab4 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele affects glucose tolerance. (J:170533)

Notes

Trait Annotation
(using the Vertebrate Trait Ontology)

organism trait

metabolism trait

glucose metabolism trait - VT:0015088

altered glucose tolerance relative to mice expressing the LG/J allele - J:170533

Mapping and Phenotype information for this QTL, its variants and associated markers

J:170533

The mice used in this study were from the F16 generation of

the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).

The authors indicated 70 trait-specific QTL mapping to 64 locations,

and of these 70 a total of 17 are significant at the genome-widelevel. Fifty three are significant at the chromosome level.

The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).

The authors mentioned that phenotypic variation in response to glucose stress was indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance.

Phenotypes were as follows:

AUC_10wks indicates under the curve at 10 weeks

AUC_20wks indicates area under the curve at 20 weeks

bGLC_10wks indicates basal glucose level at 10 weeks

bGLC_20wks indicates basal glucoselevel at 20weeks,

GLC indicates serum glucose level at necropsy

INS indicates serum insulin level at necropsy

Chr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime

2 *Ddiab4 Ddiab2a AUC_10wks 4.06 59.26 58.53 61.58

2 *Ddiab5 Ddiab2b INS 4.1369.2 67.96 70.35

2 Ddiab6 Ddiab2c GLC 3.3 73.81 71.73 76.29

2 Ddiab7 Ddiab2d GLC 3.38 99.06 93.29 99.82

2 Ddiab8 Ddiab2e INS 3.6 103.71 102.74 106.63

2 *Ddiab9 Ddiab2f AUC_20wks 4.18 145.71 145.01 147.25

Table1notes the presence of glucose and/or insulin affecting genes within the mapped QTL interval as marker G6pc2 (glucose-6-phosphatase, catalytic 2), for QTL Ddiab5; and markers Insm1 and Nkx2-2 within the interval of Ddiab9.

References

• Original: J:170533 Lawson HA, et al., The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mamm Genome. 2011 Apr;22(3-4):197-208
• All: 1 reference(s)