Ddiab45^SM/J
QTL Variant Detail

Summary

• QTL variant: Ddiab45^SM/J
• Name: diet based diabetes 45; SM/J
• MGI ID: MGI:5609708
• QTL: Ddiab45 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele affects insulin levels. (J:170533)

Notes

Trait Annotation
(using the Vertebrate Trait Ontology)

organism trait

metabolism trait

glucose metabolism trait - VT:0015088

altered insulin levels relative to mice expressing the LG/J allele - J:170533

Mapping and Phenotype information for this QTL, its variants and associated markers

J:170533

The mice used in this study were from the F16 generation of

the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).

The authors indicated 70 trait-specific QTL mapping to 64 locations,

and of these 70 a total of 17 are significant at the genome-wide level. Fifty three are significant at the chromosome level.

The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).

The authors mentioned that phenotypic variation in response to glucosestresswas indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per

gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance.

Phenotypes were as follows:

AUC_10wks indicates under the curve at 10 weeks

AUC_20wks indicates area under the curve at 20 weeks

bGLC_10wks indicates basal glucose level at 10 weeks

bGLC_20wks indicates basal glucose level at 20 weeks,

GLC indicates serum glucose level at necropsy

INS indicates serum insulin level at necropsy

Chr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime

13 Ddiab42 Ddiab13a AUC_20wks 3.06 29.67 21.92 33.36

13 Ddiab43 Ddiab13b bGLC_10wks 2.7 40.51 39.41 41.83

13 Ddiab44 Ddiab13c bGLC_10wks 2.73 61.03 57.9 62.99

13 *Ddiab45 Ddiab13d INS 4.56 68.92 67.81 73.33

13 Ddiab46 Ddiab13e AUC_20wks 3.24 87.1 86.46 88.39

13 Ddiab47 Ddiab13f AUC_20wks 3.83 96.15 93.17 97.71

13 Ddiab48 Ddiab13g bGLC_10wks 3.07 105.42 104.62 107.09

13 *Ddiab49 Ddiab13h AUC_10wks 4.75 114.7 112.87 119.12

13 Ddiab49 Ddiab13h AUC_20wks 2.91 116.61

References

• Original: J:170533 Lawson HA, et al., The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mamm Genome. 2011 Apr;22(3-4):197-208
• All: 1 reference(s)