Cpap^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cpap^{tm1c(EUCOMM)Wtsi}
• Name: centrosome assembly and centriole elongation protein; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5609807
• Synonyms: Sas-4^loxP
• Gene: Cpap Location: Chr14:56764218-56812882 bp, - strand Genetic Position: Chr14, 28.28 cM
• Alliance: Cpap^{tm1c(EUCOMM)Wtsi} page
• IMPC: Cpap gene page

Mutation origin

• Mutant Cell Line: EPD0028_7_G05
• Germline Transmission: Earliest citation of germline transmission: J:208632
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 56792283 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 56793168. The critical exon(s) is/are thus flanked by loxP sites. Cre mediated recombination (without flp expression) created the reporter knockout allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:173534)

Expression

In Mice Carrying this Mutation:	40 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpap Mutation: 44 strains or lines available

References

• Original: J:208632 Bazzi H, et al., Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
• All: 9 reference(s)