Sik2^tm1Htake
Targeted Allele Detail

Summary

• Symbol: Sik2^tm1Htake
• Name: salt inducible kinase 2; targeted mutation 1, Hiroshi Takemori
• MGI ID: MGI:5609867
• Gene: Sik2 Location: Chr9:50804101-50920373 bp, - strand Genetic Position: Chr9, 27.75 cM
• Alliance: Sik2^tm1Htake page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in white and brown adipose tissues. (J:215877)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik2 Mutation: 45 strains or lines available

References

• Original: J:215877 Horike N, et al., Downregulation of SIK2 expression promotes the melanogenic program in mice. Pigment Cell Melanoma Res. 2010 Dec;23(6):809-19
• All: 5 reference(s)