Wfdc1^tm1Bcm
Targeted Allele Detail

Summary

• Symbol: Wfdc1^tm1Bcm
• Name: WAP four-disulfide core domain 1; targeted mutation 1, Baylor College of Medicine, Mouse Center
• MGI ID: MGI:5609943
• Synonyms: Wfdc1^tm1LaczBCM
• Gene: Wfdc1 Location: Chr8:120393104-120414759 bp, + strand Genetic Position: Chr8, 68.15 cM, cytoband E1
• Alliance: Wfdc1^tm1Bcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216357
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ with a SV40 nuclear localization signal and PGK-Neo (in reverse orientation) were inserted inframe with the ATG start codon and replaced exon 1. PCR confirmed absence of transcript. Positive nuclear beta-gal was seen in the retina, prostate, skin, bladder, testis, lung and brain of adults. (J:216357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wfdc1 Mutation: 16 strains or lines available

References

• Original: J:216357 Ressler SJ, et al., WFDC1 Is a Key Modulator of Inflammatory and Wound Repair Responses. Am J Pathol. 2014;184(11):2951-64
• All: 1 reference(s)