Foxp3^{tm2.1(EGFP/cre)Shori}
Targeted Allele Detail

Summary

• Symbol: Foxp3^{tm2.1(EGFP/cre)Shori}
• Name: forkhead box P3; targeted mutation 2.1, Shohei Hori
• MGI ID: MGI:5609975
• Synonyms: Foxp3^GFPCre
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^{tm2.1(EGFP/cre)Shori} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215863
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Foxp3^{tm2.1(EGFP/cre)Shori} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxp3 (MGI:1891436)

• Mutation details: An IRES and EGFP/cre fusion followed by an FRT-flanked neomycin resistance cassette were inserted into exon 11. Flp-mediated recombination removed the selection cassette. (J:215863)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxp3 (mouse) Summary of all recombinase alleles driven by Foxp3. Alliance mouse Foxp3 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Autoimmune Pancreatitis J:234397.

References

• Original: J:215863 Miyao T, et al., Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity. 2012 Feb 24;36(2):262-75
• All: 2 reference(s)