Ightm1(IGH)Vlcg
Targeted Allele Detail
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Symbol: |
Ightm1(IGH)Vlcg |
Name: |
immunoglobulin heavy chain complex; targeted mutation 1, Velocigene |
MGI ID: |
MGI:5609985 |
Synonyms: |
18hVH |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion
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Ightm1(IGH)Vlcg involves 2 genes/genome features (Adam6b, Adam6a)
View all
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Ightm1(IGH)Vlcg expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
human |
IGH (3492) |
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Mutation details: Using BAC recombineering roughly 3 Mbp of the mouse locus including all of the Vh Dh and Jh gene segments was replaced with 340 kb of contiguous human sequence containing the equivalent human gene segments. The proximal junction of the replacement was placed about 200 bp downstream from the last J segment and the distal junction was placed about 9 kbp downstream from J558.55.
(J:208619)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh Mutation: |
44 strains or lines available
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Original: |
J:208619 Macdonald LE, et al., Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5147-52 |
All: |
3 reference(s) |
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