Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, C Clare Blackburn
• MGI ID: MGI:5613106
• Synonyms: FOXN1ER^T2, R26Foxn1ER, ROSA26^{CAG-STOP-Foxn1ERT2-IRES-GFP}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208852
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Inserted expressed sequence)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Foxn1 (MGI:102949)

• Mutation details: A cassette was inserted into the locus consisting of the CAG promoter, intron, floxed stop sequence, mouse Foxn1 cDNA fused to an ERT2 element, an IRES, and a GFP sequence. Cre mediated recombination is needed to induce protein expression. Protein activity in the presence of tamoxifen is similar to the endogenous protein. (J:208852)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:208852 Bredenkamp N, et al., Regeneration of the aged thymus by a single transcription factor. Development. 2014 Apr;141(8):1627-37
• All: 1 reference(s)