Adam23^tm1.2Mejr
Targeted Allele Detail

Summary

• Symbol: Adam23^tm1.2Mejr
• Name: a disintegrin and metallopeptidase domain 23; targeted mutation 1.2, Dies Meijer
• MGI ID: MGI:5613205
• Synonyms: Adam23^delta1
• Gene: Adam23 Location: Chr1:63484880-63635263 bp, + strand Genetic Position: Chr1, 32.31 cM
• Alliance: Adam23^tm1.2Mejr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked selection cassette and loxP site were inserted downstream of exon 1. Flp mediated recombination removed the selection cassette. Cre mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in sciatic nerve extracts from homozygous mice. (J:208847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam23 Mutation: 63 strains or lines available

References

• Original: J:208847 Kegel L, et al., Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development. 2014 Apr;141(8):1749-56
• All: 2 reference(s)