Aqp4^tm1.1Mysi
Targeted Allele Detail

Summary

• Symbol: Aqp4^tm1.1Mysi
• Name: aquaporin 4; targeted mutation 1.1, Masato Yasui
• MGI ID: MGI:5613228
• Synonyms: Aqp4^{tm1.1(GFP)Mysi}
• Gene: Aqp4 Location: Chr18:15522553-15544039 bp, - strand Genetic Position: Chr18, 8.74 cM
• Alliance: Aqp4^tm1.1Mysi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214906
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette and an EGFP reporter gene replaced 250 nucleotides in exon 1. Flp-mediated recombination removed the selection cassette. (J:214906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp4 Mutation: 46 strains or lines available

References

• Original: J:214906 Ikeshima-Kataoka H, et al., Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin. Mol Cell Neurosci. 2013 Sep;56:65-75
• All: 14 reference(s)