Cryba1^tm1.1Dbsa
Targeted Allele Detail

Summary

• Symbol: Cryba1^tm1.1Dbsa
• Name: crystallin, beta A1; targeted mutation 1.1, Debasish Sinha
• MGI ID: MGI:5613243
• Synonyms: Cryba1^fl
• Gene: Cryba1 Location: Chr11:77609441-77616109 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B-C1
• Alliance: Cryba1^tm1.1Dbsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215856
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were floxed. Flp-mediated recombination removed the neomycin selection cassette inserted downstream of exon 5. (J:215856)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cryba1 Mutation: 11 strains or lines available

References

• Original: J:215856 Valapala M, et al., Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes. Nat Commun. 2013;4:1629
• All: 8 reference(s)