Athsq3^C57BL/6J
Allele Detail

Summary

• Symbol: Athsq3^C57BL/6J
• Name: atherosclerosis susceptibility QTL 3; C57BL/6J
• MGI ID: MGI:5613586
• Gene: Athsq3 Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Athsq3^C57BL/6J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Not Applicable (Not Applicable)
• Mutation: Undefined
• This allele confers increased aortic lesion area in males on a high fat diet compared to CC3/HeJ. (J:140288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Athsq3 Mutation: 0 strains or lines available

Notes

Trait Annotation
(using the Vertebrate Trait Ontology)

organ system trait

circulatory system morphology trait

blood vessel morphology trait

aorta integrity trait - VT:0010602

aortic root lesion size is increased relative to C3H/HeJ when fed a Western diet - J:140288

Wang et al (J:140288) identified Athsq1 in F2 animals homozygous for Apoe^tm1Unc but now considered Athsq3.

References

• Original: J:140288 Wang SS, et al., Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res. 2007 Aug 3;101(3):e11-30
• All: 1 reference(s)