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Tlr4Lps-3Btlr
Chemically induced Allele Detail
Summary
Symbol: Tlr4Lps-3Btlr
Name: toll-like receptor 4; defective lipopolysaccharide response 3 Bruce Beutler
MGI ID: MGI:5613596
Synonyms: Lops
Gene: Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance: Tlr4Lps-3Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a T to A transversion at base pair 66,833,880 (v38) on chromosome 4, or base pair 6,070 in the GenBank genomic region NC_000070. The mutation lies in the splice acceptor site of intron 1 of the 3 exon gene, and affects a thymine base 14 nucleotides from the next exon. One possibility, shown below, is that aberrant splicing may result in skipping of the 167 bp exon 2, utilization of the acceptor splice site from intron 2, and splicing of exon 1 to exon 3. Deletion of exon 2 would result in a frame-shift and the coding of one aberrant amino acid followed by a premature stop codon (the second abnormal codon after exon 1). (J:217295)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  91 strains or lines available
References
Original:  J:217295 Zhang Z, et al., Mutagenetix entry for Lops. MGI Direct Data Submission. 2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory